A manhunt was underway on Friday evening for the terrorists who attacked a family near Otniel.
Meanwhile, Prime Minister Binyamin Netanyahu vowed to bring the attackers to justice.
"We will get to these heinous murderers and we will bring them to justice as we have done in the past," he said in a statement.
In the attack, the Arab terrorists opened fire on the vehicle of the victims, killing a 40-year-old man and his 18-year-old son.
A 16-year-old boy was moderately wounded. He was treated by emergency services at the scene before being transferred to a nearby hospital.
According to an initial investigation, the Arab terrorists overtook an Israeli family traveling in their car and raked it with bullets. When the car ground to a halt the terrorists continued firing at it, before driving off.
Four children who were traveling in the car were treated for shock at the scene, and evacuated to Soroka Hospital in Be'er Sheva.
IDF soldiers are currently sweeping the area in an attempt to intercept the terrorists. Defense Minister Moshe Ya’alon and IDF Chief of Staff Gadi Eizeknot ordered reinforcements to the area in order to swiftly capture the terrorists.
(Arutz Sheva’s North American desk is keeping you updated until the start of Shabbat in New York. The time posted automatically on all Arutz Sheva articles, however, is Israeli time.)